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KMID : 0363420120260020013
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Journal of Korean Oriental Pediatrics
2012 Volume.26 No. 2 p.13 ~ p.24
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Effects of Nardostachys Jatamansi on Atopic Dermatitis-like Skin Lesions
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Min Deul-le
Park Eun-Jung
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Abstract
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Objectives: NJ is being used to treat inflammatory diseases in Korea. In this study, we attempted to evaluate the effects of NJ on atopic dermatitis (AD)-like lesions and mast cell-mediated allergy inflammation in vivo and in vitro.
Methods and Results: We investigated to ascertain the pharmacological effects of NJ on 2,4-dinitrofluorobenzene (DNFB)-induced allergic reactions under in vivo conditions. Additionally, to find possible explanations for the anti-inflammatory mechanisms of NJ, we evaluated the regulatory effects of NJ on the level of inflammatory mediators in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1).
Conclusions: NJ inhibited the production of the inflammatory cytokines (IgE, IL-6, IL-8 and TNF-) significantly in vivo and in vitro.
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KEYWORD
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Nardostachys Jatamansi, Atopic dermatitis, Inflammatory cytokine, Human mast cells-1
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